منابع مشابه
Toxicity of Vitamin D
In 1999, Vieth indirectly asked the medical community to produce any evidence 10,000 units of vitamin D a day was toxic, saying, “Throughout my preparation of this review, I was amazed at the lack of evidence supporting statements about the toxicity of moderate doses of vitamin D”. He added, “If there is published evidence of toxicity in adults from an intake of 250ug (10,000 IU)/d, and that is...
متن کاملPharmacokinetics of vitamin D toxicity.
Although researchers first identified the fat-soluble vitamin cholecalciferol almost a century ago and studies have now largely elucidated the transcriptional mechanism of action of its hormonal form, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], we know surprisingly little about mechanisms of vitamin D toxicity. The lipophilic nature of vitamin D explains its adipose tissue distribut...
متن کاملVitamin D: Deficiency, Sufficiency and Toxicity
The plethora of vitamin D studies over the recent years highlight the pleomorphic effects of vitamin D outside its conventional role in calcium and bone homeostasis. Vitamin D deficiency, though common and known, still faces several challenges among the medical community in terms of proper diagnosis and correction. In this review, the different levels of vitamin D and its clinical implications ...
متن کاملVitamin D toxicity redefined: vitamin K and the molecular mechanism.
The dose of vitamin D that some researchers recommend as optimally therapeutic exceeds that officially recognized as safe by a factor of two; it is therefore important to determine the precise mechanism by which excessive doses of vitamin D exert toxicity so that physicians and other health care practitioners may understand how to use optimally therapeutic doses of this vitamin without the risk...
متن کاملHypercalcemic crisis due to vitamin D toxicity.
1. What should be included in the differential diagnosis of hypercalcemia? Are the patient’s laboratory findings consistent with her reported use of vitamin supplements? 2. What role does vitamin D play in Ca2+ homeostasis? 3. Other than excess nutritional supplement use, what are additional causes of vitamin D toxicity? 4. What are the symptoms of vitamin D toxicity? How should vitamin D toxic...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2007
ISSN: 0884-0431
DOI: 10.1359/jbmr.07s221